Contour adaptation is a recently described paradigm that renders otherwise salient visual stimuli temporarily perceptually invisible. Here we investigate whether this illusion can be exploited to study visual awareness. We found that CA can induce seconds of sustained invisibility following similarly long periods of uninterrupted adaptation. Furthermore, even fragmented adaptors are capable of producing CA, with the strength of CA increasing monotonically as the adaptors encompass a greater fraction of the stimulus outline. However, different types of adaptor patterns, such as (...) distinctive shapes or illusory contours, produce equivalent levels of CA suggesting that the main determinants of CA are low-level stimulus characteristics, with minimal modulation by higher-order visual processes. Taken together, our results indicate that CA has desirable properties for studying visual awareness, including the production of prolonged periods of perceptual dissociation from stimulation as well as parametric dependencies of that dissociation on a host of stimulus parameters. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Human beings have a tendency to transform geographical spaces into dwelling places which assume significance in terms of their social, cultural and personal identities. The authors describe the ways in which this occurs, how it is disrupted by a natural disaster - an Australian bushfire - and how the reciprocal relationship between place and person can contribute to personal and communal healing. The discussion draws on a doctoral thesis conducted by the principal author, and is illuminated by excerpts from narratives (...) provided by those who experienced the bushfire. The discussion is informed by insights from phenomenological geography and ecological philosophy. (shrink)

PURPOSE: To evaluate the effects of social support on comprehension and recall of consent form information in a study of Parkinson disease patients and their caregivers.DESIGN and METHODS: Comparison of comprehension and recall outcomes among participants who read and signed the consent form accompanied by a family member/friend versus those of participants who read and signed the consent form unaccompanied. Comprehension and recall of consent form information were measured at one week and one month respectively, using Part A of the (...) Quality of Informed Consent Questionnaire .RESULTS: The mean age of the sample of 143 participants was 71 years . Analysis of covariance was used to compare QuIC scores between the intervention group and control group . In the 1-week model, no statistically significant intervention effect was found . However, the intervention status by patient status interaction was statistically significant . In the 1-month model, no statistically significant intervention effect was found . Again, however, the intervention status by patient status interaction was statistically significant . At both time periods, intervention group patients scored higher on the QuIC than did intervention group caregivers, and control group patients scored lower on the QuIC than did control group caregivers.IMPLICATIONS: Social support played a significant role in enhancing comprehension and recall of consent form information among patients. (shrink)

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

The recent appearance of generative artificial intelligence (AI) platforms has been seen by many as disruptive for education. In this paper I attempt to locate the source of tension between educational goals and new information technologies including AI. I argue that this tension arises from new conceptions of epistemic agency that are incompatible with educational aims. I describe three competing theories of epistemic agency which I refer to as Makers, Managers, and Inforgs. I contend that educators are correct in maintaining (...) the first of these, which is rooted in the educational theories of Locke and Dewey, as their main educational purpose. Competing theories do not serve the goals of learners, even as they must prepare for life in a very different epistemic environment. (shrink)

Models of recognition memory have traditionally struggled with the puzzle of criterion setting, a problem that is particularly acute in cases in which items for study and test are of widely varying types, with differing degrees of baseline familiarity and experience (e.g., words vs. random dot patterns). We present a dynamic model of the recognition process that addresses the criterion setting problem and produces joint predictions for choice and reaction time. In this model, recognition decisions are based not on the (...) absolute value of familiarity, but on how familiarity changes over time as features are sampled from the test item. Decisions are the outcome of a race between two parallel accumulators: one that accumulates positive changes in familiarity (leading to an ‘‘old’’ decision) and another that accumulates negative changes (leading to a ‘‘new’’ decision). Simulations with this model make realistic predictions for recognition performance and latency regardless of the baseline familiarity of study and test items. (shrink)

This commentary argues against the indictment of current experimental practices such as piecemeal testing, and the proposed integrated experiment design (IED) approach, which we see as yet another attempt at automating scientific thinking. We identify a number of undesirable features of IED that lead us to believe that its broad application will hinder scientific progress.

The multiple activities of the RecA protein in DNA metabolism have inspired over a decade of research in dozens of laboratories around the world. This effort has nevertheless failed to yield an understanding of the mechanism of several RecA protein‐mediated processes, the DNA strand exchange reactions prominent among them. The major factors impeding progress are the invalid constraints placed upon the problem by attempting to understand RecA protein‐mediated DNA strand exchange within the context of an inappropriate biological paradigm – namely, (...) homologous genetic recombination as a mechanism for generating genetic diversity. In this essay I summarize genetic and biochemical data demonstrating that RecA protein evolved as the central component of a recombinational DNA repair system, with the generation of genetic diversity being a sometimes useful byproduct, and review the major in vitro activities of RecA protein from a repair perspective. While models proposed for both recombination and recombinational repair often make use of DNA strand cleavage and transfer steps that appear to be quite similar, the molecular and thermodynamic requirements of the two processes are very different. The recombinational repair function provides a much more logical and informative framework for thinking about the biochemical properties of RecA and the strand exchange reactions it facilitates. (shrink)

Research highlights several risk and resilience factors at multiple ecological levels that influence individuals’ mental health and wellbeing in their everyday lives and, more specifically, in disaster or outbreak situations. However, there is limited research on the role of these factors in the early days of the COVID-19 crisis. The present study examined if and how potential risk factors and resilience factors are associated with mental health and well-being outcomes, and whether these resilience factors buffer the associations between risk factors (...) and said outcomes. One to two weeks after the government recommended preventative measures, 1,122 Canadian workers completed an online questionnaire, including multiple wellbeing outcome scales in addition to measures of potential risk and resilience factors. Structural equation models were tested, highlighting that overall, the considered risk factors were associated with poorer wellbeing outcomes, except social distancing which was associated with lower levels of stress. Each of the potential resilience factors was found to have a main effect on one or more of the wellbeing outcomes. Moderation analysis indicated that in general these resilience factors did not, however, buffer the risk factors. The findings confirm that the COVID-19 crisis encompasses several stressors related to the virus as well as to its impact on one’s social, occupational, and financial situation, which put people at risk for lower wellbeing as early as one to two weeks after the crisis began. While several resilience factors emerged as positively related to wellbeing, such factors may not be enough, or sufficiently activated at that time, to buffer the effects of the numerous life changes required by COVID-19. From an ecological perspective, while mental health professionals and public health decision-makers should offer/design services directly focused on mental health and wellbeing, it is important they go beyond celebrating individuals’ inner potential for resilience, and also support individuals in activating their environmental resources during a pandemic. (shrink)

Although there is extensive information about why people participate in clinical trials, studies are largely based on quantitative evidence and typically focus on single conditions. Over the last decade investigations into why people volunteer for health research have become increasingly prominent across diverse research settings, offering variable based explanations of participation patterns driven primarily by recruitment concerns. Therapeutic misconception and altruism have emerged as predominant themes in this literature on motivations to participate in health research. This paper contributes to more (...) recent qualitative approaches to understanding how and why people come to participate in various types of health research. We focus on the experience of participating and the meanings research participation has for people within the context of their lives and their health and illness biographies. (shrink)

Strengths, Opportunities, Aspirations, and Results is a strengths-based framework for strategic thinking, planning, conversations, and leading that focuses on strengths, opportunities, aspirations, and results. The SOAR framework leverages and integrates Appreciative Inquiry to create a transformation process through generative questions and positive framing. While SOAR has been used by practitioners since 2000 as a framework for generating positive organizational change, its use in empirical research has been limited by the absence of reliable and valid measures. We report on the reliability, (...) construct validity, and measurement invariance of the SOAR Scale, a 12-item self-report survey organized into four first-order factors. Data from a sample of 285 U.S. professionals were analyzed in Mplus using confirmatory factor analysis and exploratory structural equation modeling. The Four-Factor first-order exploratory structure equation modeling had the best model fit. Measurement invariance tests found the scalar invariance of the SOAR Scale across gender and education groups. Implications are discussed for using the SOAR Scale to build resilience at the individual, the team, and the organizational levels. (shrink)

PERSON AND OBJECT by Roderick M. Chisholm. U.K.: Allen & Unwin; U.S.A.: Humanities Press, 1976. 230 pp. £7.25.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.1 (2002) 107-124 [Access article in PDF] Shakespeare and Political Philosophy John D. Cox Though Shakespeare has been praised as one of the greatest thinkers who ever lived, he has no standing in the history of Western philosophy, being at best a footnote to the derivative neo-Platonists and skeptics of the late Renaissance. He died in 1616, more than twenty years before Descartes's Discourse on Method (...) heralded the autonomous rationalism of the Enlightenment, and Shakespeare did not achieve a reputation as a deep thinker until the nineteenth century, as a consequence of admiration for his characters. People seemed to think that a reflective and witty prince who could say to his friend, "There are more things in heaven and earth, Horatio, / Than are dreamt of in your philosophy" must be the product of a keenly philosophical intelligence—never mind that Hamlet is referring to the "antique Roman" philosophy he so admires in Horatio, i.e., Stoicism, which by 1599 was little more than an oft-repeated set of moral and social platitudes. 1 To assert that there are more things in heaven and earth than late Renaissance Stoicism is not to assert very much.But other ways of thinking about Shakespeare philosophically are more promising than character analysis. He was indeed a thoughtful playwright, and though he had no university education, he was a voracious and incisive reader, so the influences on his plays and poems include many writers who have some standing in the history of philosophy. More complex than discerning historical philosophical influences on Shakespeare is what might be called the hermeneutical approach, i.e., the interpretation of the plays and poems with particular philosophers and philosophies in mind, regardless of their possible historical influence in the sixteenth century. To survey the range of philosophical influences and hermeneutical approaches is impossible [End Page 107] in a single essay, but a manageable example of Shakespeare's thinking is his political philosophy, where both ways of understanding him can be discerned. The most influential interpreter of Shakespeare's history plays for the second half of the twentieth century, for example, was E. M. W. Tillyard, who purported to excavate the neo-Platonic assumptions of Shakespeare's political culture: order, degree, hierarchy, and obedience. 2 Though questions were increasingly raised concerning Tillyard's assumptions and documentation, the decisive challenge to his authority was issued in the 1980s by New Historicists and Cultural Materialists, whose allegiance was more or less explicitly Marxist, and who therefore interpreted Shakespeare in light of a particular nineteenth-century philosophy. 3 A clearer example of the difference between history and hermeneutics in understanding Shakespeare is hard to imagine.The clarity of the difference, however, does not mean that the two approaches are mutually exclusive. Tillyard construed Shakespeare's emphasis on hierarchical order as an advocacy of divine-right monarchy, and much in the plays of Shakespeare supports this construal. Despite his sympathetic portraits of particular characters, including commoners, remarks in his plays about commoners taken together ("the people") are always slighting and mistrustful—often indeed scornful—and the proportion of upper-class to lower-class characters reflects their perceived social importance, for the former invariably outnumber the latter, even in the comedies, whereas the aristocracy were a tiny fraction of the total population in Shakespeare's England. Shakespeare's portrayal of pre-imperial Rome, in Julius Caesar, Antony and Cleopatra, and Coriolanus, shows little understanding of, and less sympathy with, republican alternatives to one-person rule. Shakespeare was not responsive to Calvin's spirited defense of the "poor common people" against rapacious kings (even, or especially, under godly magistrates), and Shakespeare's plays offer no support to the nascent republicanism of those who took arms against the king of England in the mid-seventeenth century, largely inspired by Calvinism. 4 Shakespeare, in short, was no Milton.This is not to say, however, that he was an uncritically idealizing royalist, as we can see from his first venture into writing about English history: his four early plays on the civil unrest of the fifteenth century. Three of these plays... (shrink)

The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds specific (...) DNA sequences, and recently major downstream targets have been identified, including p21Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21Cip1 in the cell cycle. (shrink)

The new class of anti-inflammatory drugs, the COX-2 inhibitors, have been commercially successful to the point of market dominance within a short time of their launch. They attract a price premium on the basis that they are associated with fewer adverse gastric events than traditional anti-inflammatory drugs. This marketing continues even though a pivotal safety study with one of the COX-2 inhibitors, rofecoxib, showed a significant increase in myocardial infarction with rofecoxib use compared with a traditional anti-inflammatory drug. This finding (...) has led to a series of publications containing pooled analyses of existing data that both support and refute the possibility of increased cardiovascular risk with COX-2 inhibitors.These medical journal publications have served to obfuscate rather than provide guidance for medical practitioners. Consideration of a research ethics committee approach to this issue suggests that it would deal with the controversy in a straightforward manner—namely, it would simply inform research participants of the trial results with rofecoxib. The certainty of this research ethics committee approach raises the issue of whether it should be applied in normal medical practice outside of the research environment. A consideration of the legal tests for disclosure of information suggests that therapeutic medical practice should mirror that within the research environment, in this case. (shrink)

Continues the ongoing dialogue between religion and science. In this volume, the author has focused on scientific or science-based technology rather than just the significance of 'pure science'. This complex focus covers a number of issues including scientific theory, public policy, ethical consideration, cosmology, theological conundrums and the age-old issues of the meaning of human life and its fulfillment.

The many conflicting views that have given rise to the contemporary crisis in religious thought can be traced to certain figures who have played a major role in the shaping of present-day thinking. An exploration of the ideas of these philosopher-theologians, from Schleiermacher and Kierkegaard to Barth, Tillich, Maritain, Berdyaev, Buber, and such lesser figures as Dietrich Bonhoeffer, Harvey Cox, Thomas Altizer, and Richard Rubenstein, has been the chief objective of the author of this work. His survey of modern and (...) contemporary religious thinking, which he conducted within a predominantly Protestant framework, has convinced him that a common theme runs through the writings of the men examined by him: the problem of God is inseparable from the problem of modern man. "In the minds of theologians," the author asserts, "the loss of certainty about God is at base a loss of a sense of ultimacy which gives depth and purpose to everyday living.... And so, in responding to the loss of ultimacy, modern theology has reintroduced the question of man himself: his life and death, his experiences of tragedy, joy, guilt, acceptance, loss, and love." While pointing to the radical differences among theologians in their explanations of man's loss of faith, Idinopulos suggests that the theological options offered by such men as Barth, Tillich, Maritain, Berdyaev, and Buber are of paramount importance for the understanding of today's religious thinking. In his final chapter, the author makes a critical appraisal of the chief representatives of "secular theology," such as Bonhoeffer, Cox, and Altizer; and analyzes Rubenstein's peculiar theory of Holy Nothingness, or "Sacred Void out of which we came and to which we return." The author's analysis makes clear the extreme confusion, and even outright absurdity, into which men have been led by the self-styled "Theologians in a World Come of Age," which is the title of the chapter. The volume closes with a selected bibliography for each of the authors discussed and a comprehensive index.--B. M. B. (shrink)

David Berry and Michael Dieter: Introduction -- Florian Cramer: What is post-digital? -- Malcolm Levy and Christine Paul: Genealogies of the new aesthetic -- David Berry: The post-digital constellation -- Lukacs Mirocha: Communication models, aesthetics and ontology of the computational age revealed -- Katja Kwastek: How to be theorized: a f*** academic essay on the new aesthetic -- Daniel Pinkas: A hyperbolic new aesthetic -- Stamatia Portanova: The genius and the algorithm: reflections on the new aesthetic as a computer's vision (...) -- Lev Manovich and Alise Tifentale: Selfiecity: exploring photography and self-fashioning in social media -- David Golumbia: Judging like a machine -- Caroline bassett: Not now? : feminism, technology, postdigital -- Geoff Cox: Postscript on the problem of temporality in the post-digital -- Michael Dieterdark: Patterns: interface design, augmentation and crisis -- Sean Cubitt: Data visualisation and the subject of political aesthetics -- Mercedes Bunz: School will never end: on infantilization in digital environments: amplifying empowerment or propagating stupidity? -- Jussi Parikkathe : City and the city: London 2012 visual (un)commons -- Shintaro Miyazaki: Going beyond the visible: new aesthetic as an aesthetic of blindness? -- Thomas Apperley: Glitch sorting: minecraft, curation and the postdigital -- Marc Tuters: Through glass darkly: Google's gnostic governance -- Vito Campanelli: New aesthetic in the perspective of social photography -- Søren Bro Pold and Christian Ulrik Andersen: Aesthetics of the banal: "new aesthetics" in an era of diverted digital revolutions -- Wendy Chunnet: Works now: belated too early. (shrink)

When people engage in conversation, they tailor their utterances to their conversational partners, whether these partners are other humans or computational systems. This tailoring, or adaptation to the partner takes place in all facets of human language use, and is based on a mental model or a user model of the conversational partner. Such adaptation has been shown to improve listeners' comprehension, their satisfaction with an interactive system, the efficiency with which they execute conversational tasks, and the likelihood of achieving (...) higher level goals such as changing the listener's beliefs and attitudes. We focus on one aspect of adaptation, namely the tailoring of the content of dialogue system utterances for the higher level processes of persuasion, argumentation and advice-giving. Our hypothesis is that algorithms that adapt content for these processes, according to a user model, will improve the usability, efficiency, and effectiveness of dialogue systems. We describe a multimodal dialogue system and algorithms for adaptive content selection based on multi-attribute decision theory. We demonstrate experimentally the improved efficacy of system responses through the use of user models to both tailor the content of system utterances and to manipulate their conciseness. (shrink)